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Article No. 27

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Carbapenams (Meropenem, Imipenem, Ertapenem)
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Carbapenams (Meropenem, Imipenem, Ertapenem)

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Publish Date: May 10, 2017
Table of Contents

Mechanism of Action

  • Binds peptidoglycan binding protein to inhibit the cross-linking of peptidoglycan, therefore inhibiting bacterial cell wall synthesis. 
  • Beta-lactamase resistant
  • Carbapenems are inactivated in the renal tubules by renal dihydropeptidase I. 
  • Cilastin is a drug often given with carbapenems, which inhibits the renal inactivation of carbapenems which increases their duration of action. 

Clinical Use

Broad-spectrum

  • Gram-positive cocci 
    • Enterococcus
  • Gram-negative rods 
    • Enterobacter spp.
    • Klebsiella spp.
    • Pseudomonas spp.
  • Anaerobes

*not effective against VRE or MRSA

Side Effects

  • GI upset
  • Allergic Reaction
  • Seizures - especially with renal insufficiency, secondary to high serum levels

About the Author
MedFarm Pharmacology
We love drugs, medical FDA approved drugs that is. MedFarm is a channel for everything pharmacology

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