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Fluoroquinolones
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Fluoroquinolones

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Category:
#infectious
Publish Date: May 7, 2017
Table of Contents

Mechanism of Action

A family of synthetic broad-spectrum antibiotics, fluoroquinolones inhibit the activity of DNA gyrase (topoisomerase II) by preventing bacterial DNA from unwinding and duplicating.

Clinical Use

In general the fluoroquinolones will cover common microbes causing urinary tract infections, GI infections, pneumonias and gonorrhea:

Gram-negative

  • Pseudomonas 
  • Neisseria
  • Haemophilus
  • Klebsiella
  • E. coli
  • Legionella

Gram-positive organisms

  • Enterobacter

Mycoplasma

There are "respiratory fluoroquinolones" (gatifloxacin, levoquin, moxifloxacin) that have increased activity against some gram-positive organism such as S. pneumoniae and staph species.

Side Effects

  • Rash
  • Tendonitis and tendon rupture
  • GI upset

Contraindications

Should not be used in pregnancy since fluoroquinoles have been shown to cuase damage to growing cartilage

About the Author
MedFarm Pharmacology
We love drugs, medical FDA approved drugs that is. MedFarm is a channel for everything pharmacology

Fluoroquinolone Molecule

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