Aminopenicillins - (Amoxicillin, Ampicillin)

Binds peptidoglycan binding protein to inhibit the cross-linking of peptidoglycan, therefore inhibiting bacterial cell wall synthesis.

Aminopenicillins are sensitive to penicillinase, so they are often paired with beta-lactamase inhibitors to protect them against breakdown because of this sensitivity.

Aminopencillins are extended spectrum penicillins, meaning they will cover more infections.

They are often used to treat infections cause by:

• gram-negative rods (H. influenze, H. pylori, E. coli, Listeria monocytogenes, Proteus mirabilis, Salmonella

You can think of the HHELPS bugs

• gram-positive cocci - Enterococcus

• allergic reactions 
• hypersensitivity, skin rash
• pseudomembranous colitis

These antibiotics are sensitive to penicillinase which will cleave their beta-lactam ring

Amoxicillin is typically given in the oral form

amOxicillin - think Orally